Peter Highman (Robert Downey Jr.) must get to LA in five days to be at the birth of his firstborn. He is about to fly home from Atlanta when his luggage and wallet are sent to LA without him, and he is put on the "no-fly" list. Desperate to get home Peter is forced to accept the offer of Ethan Tremblay (Zach Galifianakis) to hitch a ride with him cross-country. Peter is about to go on the most terrifying and agonizing journey of his life. Enroute from Atlanta to Los Angeles via plane to be on time for the birth of his first child, Peter Highman instead runs into fellow-passenger/aspiring Hollywood actor, Ethan Tremblay, and has part of his baggage switched. Just when the flight is about to take off, Peter gets into a situation, is shot and subdued by an Air Marshall. When he regains his senses he finds he is on the 'No Fly List', no money/credit card, nor identification, and is compelled to hitch a ride with Ethan. Hoping to make it in time, he is has no idea that soon he will be assaulted by a 'handicapable' Western Union employee; get in a serious accident that will result in a fracture and several stitches; be on the run from Mexican Police; suspect his wife of having an affair with his friend, Darryl, and that the child may not even be his!
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