Set in Pasadena, California, the show is centered on five characters: two roommate geniuses who work at the California Institute of Technology, experimental physicist Leonard Hofstadter and theoretical physicist Sheldon Cooper; their neighbor across the hall Penny, a blonde waitress and aspiring actress; and Leonard and Sheldon's equally geeky and socially awkward co-workers and friends Howard Wolowitz, an aerospace engineer and a non-PhD from JPL, and Rajesh Koothrappali, an astrophysicist also working at Caltech. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense. Three other supporting characters have also been promoted to main cast status for a few episodes: Leslie Winkle, a Caltech colleague and ex-lover of both Leonard and Howard; Bernadette Rostenkowski, a microbiology graduate who has worked with Penny part-time as a waitress, dated and recently become engaged to Howard, and earned her PhD; and Amy Farrah Fowler, a neurobiologist who was hooked up with Sheldon via an online dating service (courtesy of Howard and Raj, who were later horrified when Amy turned out to be essentially a female version of Sheldon).
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